One injection treats and controls swine respiratory disease for 7 days. Lung lesions were scored and lungs were submitted for bacterial identification. A total of 706 pigs with clinical signs of bacterial respiratory disease were enrolled and treated with a placebo injection or EXCEDE FOR SWINE Sterile Suspension 100 mg/mL administered as a single IM injection in the post-auricular region of the neck.
Responses to treatment were evaluated 7 days post-treatment. There were no adverse systemic effects observed, indicating that ceftiofur sodium has a wide margin of safety when administered intramuscularly in feeder pigs.A separate study evaluated the injection site tissue tolerance of EXCEDE FOR SWINE Sterile Suspension 100 mg/mL in swine when administered intramuscularly as a single injection at the maximum recommended dose volume of 2 mL (approximately 5 mg CE/kg BW) per injection site.
Do not vary from the labeled route of administration as this can affect the length of meat or milk withdrawal times and could lead to violative milk residues and extended withdrawal times. The products discussed herein may not have marketing authorization or may have different product labeling in different countries.
The susceptibility results for the treatment and control studies are presented in Table 2.Based on pharmacokinetic data from studies of ceftiofur in swine after a single intramuscular injection of 2.27 mg CE/lb (5.0 mg CE/kg) BW, the following interpretive criteria are recommended by CLSI:The effectiveness of a single dose of 2.27 or 3.18 mg CE/lb BW (5.0 or 7.0 mg CE/kg BW) EXCEDE FOR SWINE Sterile Suspension 100 mg/mL for the treatment of SRD was confirmed in a well-controlled, multi-location field study. Pigs heavier than 88 lb (40 kg) will require more than one injection.Most animals will respond to treatment within three to five days. Excede® for swine is indicated for the treatment and control of swine respiratory disease (SRD) caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis and Streptococcus suis. National Hog Farmer is part of the Informa Markets Division of Informa PLCThis site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Remove contaminated clothing. The treatment success rate was significantly higher (p = 0.0188) for EXCEDE FOR SWINE-treated pigs (59.6%) compared to the saline-treated pigs (41.4%).
There was a statistically significant (p<0.05) improvement in clinical cure rates for the EXCEDE FOR SWINE Sterile Suspension 100 mg/mL-treated groups (24.8% for the 5.0 mg CE/kg BW group and 26.4% for the 7.0 mg CE/kg BW group) compared with the placebo-treated control group (17.7%). Consequently, the information provided on the site in which you enter may not be suitable for use in your country.This site is intended for U.S. Half of the injection sites at both 3 and 7 days post-injection were scored as "negative" for irritation and the other half were scored as "slight irritation". The injections were well tolerated in all pigs. At 3, 7 and 10 days post-injection, pairs of animals were euthanized and the neck injection sites were dissected for pathological examination (4 injection sites per time point). NOT FOR HUMAN USE.
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