It is a broad-spectrum cephalosporin antibiotic active against Gram-positive and Gram-negative bacteria including B-lactamase-producing strains treat metritis. Remove contaminated clothing. INDICATIONS: EXCEDE Sterile Suspension is indicated for the treatment of Bovine Respiratory Disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni (formerly Haemophilus somnus) in beef and non-lactating dairy cattle.. Therefore, studies conducted with ceftiofur sodium are adequate to evaluate the systemic safety of EXCEDE Sterile Suspension. Like other ß-lactam antimicrobials, ceftiofur exerts its inhibitory effect by interfering with bacterial cell wall synthesis. Repeated or prolonged exposure may lead to sensitization. In the case of accidental eye exposure, flush with water for 15 minutes. Care should be taken to not insert the needle through the cartilage of the ear. As with other parenteral injections, localized post-injection bacterial infections may result in abscess formation. The product information provided in this site is intended only for residents of the United States. In the TAS study, there were no treatment related gastrointestinal findings for the three EXCEDE Sterile Suspension treatment groups. See Figures 2 and 3.● Adjust the needle insertion point to avoid any blood vessels, previous implants, ear tags or ear tag holes. Cows with a non-fetid discharge, and a rectal temperature < 103 °F, and that did not require alternate (“escape”) therapy during the 14-day observation period were classified as a cure. EXCEDE ® (ceftiofur crystalline free acid) Sterile Suspension is indicated for the treatment of lower respiratory tract infections in horses caused by susceptible strains of Streptococcus equi subspecies zooepidemicus (S. zooepidemicus). Injection site reactions developed within 2 days of injection and resolved within 1-18 days. All treatments were administered subcutaneously in the middle third of the posterior aspect of the ear. Intra-arterial injection at this location resulted in direct administration of the oil-based formulation into the arterial blood supply of the brain resulting in embolism and death.Since intra-arterial injection was confirmed in three animals that died following injection of EXCEDE Sterile Suspension, the consequences of purposeful intra-arterial injection of EXCEDE Sterile Suspension were investigated in feeder cattle. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data.The following adverse events for horses are listed in decreasing order by system and decreasing order within system classes.Injection site reactions: swelling, pain, inflammation, infection, necrosis, muscle stiffness, fibrosis, injection site stiffness/ reluctance to move, hair change, lameness, granuloma.Systemic: fever, lethargy, edema at locations other than injection site, anorexia.Gastrointestinal: colic, diarrhea.Neurologic: ataxia, muscle tremor, seizure, loss of consciousness.Immune (Allergic reactions): anaphylaxis, urticaria, allergic edema (face, face and neck, lip, or limb edema).In some cases, death has been reported as an outcome of the adverse events listed above.

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